MULTIPLE TOE-PINCH METHOD FOR TESTING ANALGESIC DRUGS

Toe Pinch Force in Male Type 2 Diabetes Mellitus Patients.

We compared the toe pinch force in men with and without type 2 diabetes mellitus (T2DM). Sixty-eight male T2DM patients and 35 apparently healthy men matched for age, sex, and body mass index (BMI) were enrolled in this cross-sectional study. We compared the toe pinch force between the subjects with and without T2DM, and we evaluated the effect of diabetic polyneuropathy on toe pinch force in t...

Pharmacogenetics of analgesic drugs

• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. • Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one of the most valuable but equally dangerous groups of medications. • While pharmacokinetic properties of drugs, metabolism in particular, ...

The Pinch Design Method for Networks

A novel method is presented for the design of heat exchanger networks. The method is the first to combine sufficient simplicity to be used by hand with near certainty to identify “best” designs, even for large problems. “Best” designs feature the highest degree of energy recovery possible with a given number of capital items. Moreover, they feature network patterns required for good controllabi...

A scalarization-based method for multiple part-type scheduling of two-machine robotic systems with non-destructive testing technologies

This paper analyzes the performance of a robotic system with two machines in which machines are configured in a circular layout and produce non-identical parts repetitively. The non-destructive testing (NDT) is performed by a stationary robotic arm located in the center of the circle, or a cluster tool. The robotic arm integrates multiple tasks, mainly the NDT of the part and its transition bet...

Testing urine for drugs